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PrecISE Asthma Research Study

Finally received my first round of new research treatment. It is Imatinib and is currently a cancer drug. I am extremely eager to try this, despite being on Dupixent since March 31st of this year and still struggling with my trigger response still being crazy. I am wondering if the wildfire smoke pollution has had a huge impact on my asthma. Anyone else feel a huge impact from the constant assault on our lungs from the wildfire pollution?

I'm attaching a link about this drug, the Doctor mentioned is my pulmonologist now at the University of Kansas Health System and school of medicine: https://medicine.wustl.edu/news/cancer-drug-may-help-patients-severe-asthma/

  1. Thanks for furnishing the community with the link to this trial drug as a possible future treatment for severe asthma. I am indeed happy to hear you've begun treatment, . I send thoughts of hope that this has a positive effect on your health. Can I ask if you are still able to take the Dupixent along with the research drug? Or have they asked you to stop it? Struggling with trigger responses can be overly challenging. Has your physician offered you any help with this issue? When I lived in a small town up in the mountains a few years back, I would have awful breathing problems when wildfires started up or prescribed burns would take place. It was infuriating when I stepped outdoors and got mauled by the heavy smoke in the air that would last months. Glad we have moved on and do not deal with this currently - as it was tough. It seems many people with breathing issues and chronic respiratory illness due to the superabundance of fires currently or recently happening are having a wretched time managing. I hope others in the community chime in with their experiences with smoke and/or wildfires. Warmly - Rebecca (community moderator)

    1. I didn't have to stop the Dupixent. I was on Fasenra when I started the study September 2021 and when I switched in March 2023, that kicked me out because of being a major med change.


      I see my pulmonologist next month. I have been anemic recently, I think it might be from the Imatinib, so I have not had a chance to test out trigger areas, but I believe I'm on real medicine not placebo.

    2. Hi again, , and thank you for sharing this with the community. I am hopeful others in the community will see your comment / inquiry and respond by sharing their own anecdotal experiences managing the effects of the various wildfires in the atmosphere.
      You may be aware we have several publications, right here on asthma.net, which focus on these world-wide wildfires. I thought it might be of interest for you to look them over. For your convenience, here is a link to one of them: https://asthma.net/clinical/wildfire-impact. I will be happy to link you to other articles should you be interested going forward.
      I will wish you 'good luck!' with your visit with the pulmonologist next month. Please do check back and keep us apprised of your progress.
      Wishing you well,
      Leon L (author / site moderator asthma.net)

  2. Thank you!

    1. G'afternoon, - you are most welcome! If we can assist you in any way, please let me or any other moderator / team member know. You are always welcome here in our online community.
      Have a great weekend!
      Leon L (author / site moderator asthma.net)

  3. Imatinib, primarily a cancer drug, has been recommended by your pulmonologist for severe asthma. Wildfire smoke pollution can exacerbate asthma symptoms, and its impact can vary based on factors like proximity and duration of exposure. Follow your doctor's advice, take precautions during smoke events, and communicate any changes in symptoms to your healthcare team for personalized guidance.

    1. The imatinib is from the PrecISE research study, starting week 3. The lead investigator at my research site is my pulmonologist. He switched me in March of this year from Fasenra to Dupixent. Not seeing as much benefit from the Dupixent as I expected, especially with all the TV commercial hype.

    2. The Link in my post has been fixed, this is the new site.




      There isn't anything official, but I believe the imatinib drastically reduced my hemoglobin.


      Not sure, but my platelets have been very high before starting this, I think I had discovered somewhere that this is another bookmark for severe asthma.


      https://source.wustl.edu/2017/05/cancer-drug-may-help-patients-severe-asthma/

  4. Not sure why it was never seen or read, but here was my update from a couple months ago.
    https://asthma.net/stories/imatinib-for-asthma


    1. Hi again, stradec - thanks so much for following up with the community here. We appreciate your diligence!
      Have a good weekend!
      Leon L (author/moderator asthma.net)

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