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Word/Phrase of the Day- Luminal Eosinophilia

Taken from a throwback on the “word/phrase of the day” of the day phenom. This is a word that you either discover more about or try to use in everyday conversation over a single day. I usually send or receive a science word as word or phrase of the day from asthma peeps, via iMessage or text message. This is usually a way to show the joy of learning something new. Often in this circle of friends, it’s an asthma fact, new discovery or even something to ruminate on.

What is luminal eosinophilia?

Today my word/phrase of the day is luminal eosinophilia. Like most things in life, it was a quick Google search to try and figure out what this referenced. I know that you are asking yourself, what is it? Or perhaps you already know what it is? Luminal Eosinophilia is the presence of eosinophils in the lumen.1 Eosinophils are connected to inflammation, which contributes to luminal obstruction. This obstructions can lead to airflow limitation, ventilation heterogeneity and symptoms. Understanding more about the inflammation and ways to treat it will help to guide treatment decisions.

There is research being conducted to get a better understanding of how eosinophils get into the lumen (trafficking) and what the mechanisms of resolution are.2

The role on inflammation in asthma

In particular, there’s recent research on how eosinophil apoptosis3, essentially, how eosinophils die without causing more inflammation. Eosinophils, release granulocytes that are involved in a host of site defenses and allergic inflammation. The theory is that increased epithelial eotaxin-2 and 3 in asthma (including severe asthma) may contribute to eosinophil migration in the lumen, especially in later onset disease.4 This may be a predictor of more severe disease or process. The research is looking at the way this understanding may determine better courses of treatment or disease understanding. It is a lot to get your head around and honestly I had to research and look at some of the migration diagrams many times before I could get a handle on the concepts.

Learning new things to be a better asthma advocate

I try to stretch myself by learning something new. Also, it helps me keep up in conversations with my physician. The more I know, the better I will be able to participate in making decisions about my care. This also helps ward off the dazed and confused look that sometimes accompany medical appointments.

Next time, the phrase may be Mast Cell tryptase….

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The Asthma.net team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

  1. https://thorax.bmj.com/content/thoraxjnl/early/2012/09/25/thoraxjnl-2012-201634.full.pdf
  2. Lung Tissue Eosinophils May Be Cleared Through Luminal Entry Rather Than Apoptosis American Journal of Respiratory and Critical Care Medicine 164(10 Pt 1):1948-56.December 20013.
  3. Evan G, Littlewood TA matter of life and cell death.Science281199813171322
  4. Meagher LC, Cousin JM, Seckl JR, Haslett COpposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol
  5. Svenningsen, Sarah & L Eddy, Rachel & Lim, Hui Fang & Cox, Gerard & Nair, Parameswaran & Parraga, Grace. (2018). Sputum Eosinophilia and MRI Ventilation Heterogeneity in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 197. 10.1164/rccm.201709-1948OC.

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