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AirDuo RespiClick (fluticasone propionate and salmeterol)

Reviewed by: HU Medical Review Board | Last reviewed: June 2023

AirDuo RespiClick® (fluticasone propionate and salmeterol) is a combination inhaler that has an inhaled corticosteroid and a long-acting beta-agonist (LABA). It comes as a dry-powder inhaler and a digihaler. A generic inhaler is available as well. AirDuo RespiClick is approved for the treatment of asthma in people 12 years of age and older.1

AirDuo RespiClick is used to control symptoms of asthma but not to relieve acute symptoms (an asthma attack) because it does not work quickly enough. Use a rescue inhaler (short-acting beta agonist) instead.1

How does AirDuo RespiClick work?

AirDuo RespiClick contains 2 medicines that work together to improve breathing:1

  • Fluticasone propionate is an inhaled corticosteroid. This medicine reduces inflammation in the airways
  • Salmeterol is a LABA. This medicine works by relaxing the muscles around the airways to help open them up

What are the ingredients in AirDuo RespiClick?

The active ingredients in AirDuo RespiClick are fluticasone propionate and salmeterol xinafoate.1

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What are the possible side effects?

The most common side effects of AirDuo RespiClick include:1

  • Infection of the nose and throat
  • Thrush in the mouth or throat
  • Back pain
  • Headache
  • Cough

LABAs, including salmeterol, have been linked to an increased risk of death and hospitalizations related to asthma when they are used by themselves. This risk has not been shown when LABAs are combined into one inhaler with inhaled corticosteroids, such as AirDuo RespiClick.2

These are not all the possible side effects of AirDuo RespiClick. Talk to your doctor about what to expect when taking AirDuo RespiClick. You should also call your doctor if you have any changes that concern you when taking AirDuo RespiClick.

Other things to know

AirDuo RespiClick is not for sudden asthma symptoms. If you have an asthma attack, use the rescue inhaler prescribed by your doctor.

AirDuo RespiClick delivers a very fine powder that you may not taste or feel. Do not take an extra dose if you do not taste or feel the medicine.1

If you take too much of this medicine, call your doctor. Go to the hospital emergency room if you have shortness of breath, chest pain, increased heart rate, or shakiness.1

Do not stop using this medicine without talking to your doctor first.

While using AirDuo RespiClick, do not take any medicines that contain LABA, such as salmeterol, formoterol fumarate, arformoterol tartrate, and indacaterol. Talk to your doctor if you are not sure if a medicine contains LABA.1

Call your doctor right away if:1

  • Your breathing problems get worse
  • You need to use your rescue inhaler more often than usual
  • Your rescue inhaler does not work as well to relieve your symptoms
  • Your peak flow meter results decrease
  • You have asthma and your symptoms do not improve after using this medicine regularly for 1 week

There is not enough information about this medicine to know whether it is safe to use when pregnant or breastfeeding. Before taking this medicine, talk to your doctor if you are pregnant or breastfeeding, or plan to become pregnant.1

Before beginning treatment for asthma, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of AirDuo RespiClick.