Due to Dupixent, I had a terrible, jabbing pain in my knee and loss of use of my right leg. I lost much sleep and was on a walker for months. It helped my asthma but the pain was intolerable. I stopped Dupixent. The jabbing pain decreased and I gradually got use of my right leg back. I have read that about 6% of patients get these symptoms. I would not recommend Dupixent to anyone.