Hi. slh122. I actually had to Google Wixela Inhub and I see that it is the same as Advair here in the U.S. And that is an inhaler that I used for many years. For me, it did not cause nervousness. But, to the contrary, it was other similar medicines like Symbicort and Breo that caused that for me. This is a testament to how these medicines effect each of us in unique ways. For the Wixela Inhub, the 500 is a steroid, and that shouldn't cause tremors or nervousness. But the 50 is the long-acting beta agonist (LABA) , and this is the medicine that would cause these symptoms. As you switch inhalers, the LABA may be different and effect you differently (as I have experienced). And I certainly would share your frustration with your insurance forcing you to change inhalers, as I have had the same happen. What is the generic inhaler you are trying now? How is that working for you? Just curious. John. Community Moderator. asthma.net