Arnuity Ellipta (fluticasone furoate)

Arnuity Ellipta (fluticasone furoate) is an inhaled corticosteroid.1 Arnuity Ellipta is approved for the long-term treatment of asthma for people ages 5 years and up. It is made by GlaxoSmithKline. Arnuity Ellipta comes as a dry powder inhaler.

Do not take Arnuity Ellipta if you are having an asthma attack. It does not work quickly enough. Use a rescue inhaler (short-acting beta agonist) instead.

How does Arnuity Ellipta work?

Inhaled corticosteroids such as Arnuity Ellipta reduce inflammation in the airways.1 Corticosteroids affect many different types of inflammatory cells, including eosinophils and mast cells. They also affect signaling chemicals that have a role in inflammation such as histamine, leukotrienes, and cytokines.

How is Arnuity Ellipta taken?

Ask your health care provider or respiratory therapist to show you how to use your inhaler properly.

Arnuity Ellipta is light gray and orange dry powder inhaler.1 It comes in strengths of 50 mcg, 100 mcg, and 200 mcg. One inhalation should be taken once daily at around the same time every day (Table 1).2

Table 1. Using your Arnuity Ellipta Inhaler

Do not open the cover until you are ready to take your dose. Opening the cover loads a dose, so if you close the cover without using the medication, you will lose that dose.
The steps for using your Arnuity Ellipta are:
  1. Open the inhaler: Slide the cover down so that you can see the mouthpiece. You will hear a click as the counter goes down by 1.
  2. Turn away from the inhaler and breathe out until your lungs are empty. (If you breathe into the inhaler, you will lose the dose of medicine.)
  3. Put your lips on the mouthpiece. Take a long, steady, deep breath through your mouth. Be sure to that your fingers do not block the air vent at the top of your inhaler. (You may not feel or taste the medicine. Do not take another dose.)
  4. Remove the inhaler from your mouth. Hold your breath for 3 to 4 seconds.
  5. Breathe out slowly.
  6. Slide the cover back over the mouthpiece to close the inhaler.
  7. Rinse your mouth with water and spit out the water. This step will help to prevent thrush, a fungal infection of the mouth.
  • Read the Patient Information that comes with your inhaler for complete instructions.

Arnuity Ellipta [patient information]. Research Triangle Park, NC: GlaxoSmithKline; 2014.

What are the recommendations for storing, cleaning, and discarding Arnuity Ellipta?

Arnuity Ellipta comes in a foil tray. Store it in the unopened tray until you are ready to use it.1 Keep Arnuity Ellipta at room temperature (68˚F and 77˚F) in a dry place. You do not need to clean your inhaler routinely.2 If needed, you can wipe the mouthpiece with a dry tissue. Throw away your inhaler six weeks after opening the foil tray or when the counter reads 0.1

What are the possible side effects of taking Arnuity Ellipta?

Taking Arnuity Ellipta could cause your airways to tighten suddenly (“bronchospasm”).1 This side effect can happen right after using the inhaler. Take your rescue inhaler and call your health care provider.

Common side effects when using Arnuity Ellipta are runny nose, sore throat, headache, breathing problems, upper respiratory tract infections, and flu.2 This is not an exhaustive list of side effects.

Inhaled corticosteroids, such as Arnuity Ellipta, can cause thrush, a fungal infection in your mouth.2 You can help to prevent this by rinsing your mouth with water after using the inhaler and spitting out the water.

Corticosteroids can lower your immune system, so you are more likely to get an infection.1 Avoid contact with people who have chickenpox, measles, or other contagious diseases. Let your provider know if you have any infections, including tuberculosis or herpes simplex of the eye.

Children who use corticosteroids may grow more slowly. Your child’s growth should be checked regularly.2

This is not an exhaustive list of side effects of Arnuity Ellipta. Talk to your healthcare provider about potential side effects.

Are there people who should not take Arnuity Ellipta?

Do not take Arnuity Ellipta if you are having an asthma attack.1 Arnuity Ellipta does not work quickly enough. A rescue inhaler should be used instead.

People with a severe milk allergy should not take the Arnuity Ellipta.2 If you are allergic to any ingredient in Arnuity Ellipta, you should not take this medication.

Tell your health care provider if you have had problems with your liver, eyes, immune system, or osteoporosis.2 Taking corticosteroids may worsen these conditions. Extra monitoring or an alternative treatment may be needed. Tell your health care provider about any prescription medications you take, particularly corticosteroids, antifungals, or anti-HIV medications. Let your provider know about over-the-counter medications or supplements that you take.

Arnuity Ellipta has not been well studied in pregnant or breastfeeding women.2 Little is known about whether this medication passes into breast milk. Talk to your doctor about if you become pregnant or wish to breastfeed while taking Arnuity Ellipta.

Is there a generic alternative to Arnuity Ellipta?

There is no generic alternative to the Arnuity Ellipta.

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Written by: Sarah O'Brien | Last Reviewed: April 2021.