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Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol)

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By Editorial Team

2 min read

Reviewed by: HU Medical Review Board | Last reviewed: June 2023

Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) is used for the maintenance treatment of asthma in people 18 and older. Trelegy Ellipta is an inhaled medicine that contains 3 ingredients that work together to improve asthma and COPD symptoms.1

Trelegy Ellipta is the first inhaler that contains 3 medicines that can be used once a day for maintenance treatment of both asthma and COPD. It is not used to relieve an asthma attack.1,2

What are the ingredients in Trelegy Ellipta?

The active ingredients in Trelegy Ellipta include:1,3

  • Fluticasone furoate
  • Umeclidinium
  • Vilanterol

How does Trelegy Ellipta work?

Trelegy Elipta contains 3 ingredients in an inhalation powder form that help make it easier to breathe:1,3

  • Fluticasone is an inhaled corticosteroid (ICS). It helps decrease inflammation in the lungs.
  • Umeclidinium is an anticholinergic drug. It is also called a long-acting muscarinic antagonist (LAMA). Umeclidinium helps open up air passages so you can get more air into the lungs.
  • Vilanterol is a long-acting beta-agonist (LABA). It helps relax bronchial smooth muscles. Vilanterol also keeps the muscles from getting too tight.

What are the possible side effects?

The most common side effects of Trelegy Ellipta include:1,3

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  • Upper respiratory tract infection
  • Sinus infection
  • Throat pain
  • Nasal symptoms (runny or stuffy nose)
  • Pneumonia
  • Bronchitis
  • Fungal infection in the mouth
  • Headache
  • Back or joint pain
  • Flu
  • Change in taste
  • Constipation, diarrhea, or stomach “bug”
  • Urinary tract infection
  • Cough
  • Feeling unwell or unhappy

Rare side effects of Trelegy Ellipta may include:1,3

  • Allergic reactions like rash, hives, or anaphylaxis (trouble breathing)
  • Cardiovascular effects like increased pulse or blood pressure, or irregular heartbeat
  • Reduced bone mineral density

These are not all the possible side effects of Trelegy Ellipta. Talk to your doctor about what to expect or if you experience any changes that concern you during treatment with Trelegy Ellipta.

Other things to know

Take Trelegy Ellipta at the same time each day. Rinse and spit with water after using Trelegy Ellipta. Rinsing helps prevent fungal infections of the mouth.1,3

Do not use Trelegy Ellipta if you have an allergy to milk proteins.1,3

Trelegy Ellipta is for the maintenance treatment of asthma and COPD. Trelegy will not help if you have sudden breathing problems. It is not a rescue inhaler. You should always carry a rescue inhaler with you.1,3

Trelegy Ellipta can worsen glaucoma and bladder or prostate problems. This medicine should be used carefully in people with these conditions.1,3

Talk to your doctor before using Trelegy Ellipta if you have:1,3

  • Heart problems
  • High blood pressure
  • Seizures
  • Thyroid problems
  • Diabetes
  • Liver problems
  • Weak bones
  • A weak immune system

It is not known if Trelegy Ellipta is safe and effective for children.1,3

There is not enough information about Trelegy Ellipta and pregnancy to know if this drug is safe to use when pregnant or breastfeeding. The risk of birth defects and miscarriage is not known. Before using this drug, tell your doctor if you are pregnant or plan to become pregnant.1,3

Tell your doctor about any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information for Trelegy Ellipta.