I took Symbicort for years using a spacer and never had an issue. Insurance dropped Symbicort and my asthma doctor put me on Fluticasone propionate and Salmeterol HFA Inhalation Aerosol with spacer. I have had thrush twice in the first year. I always rinse my mouth thoroughly with diluted lysterine after each use. Nystatin got rid of it but it has come back.